trouble an effort that is inconvenient; "I went to a lot of trouble"; "he won without any trouble"; "had difficulty walking"; "finished the test only with great difficulty"
pity,
shame an unfortunate development; "it's a pity he couldn't do it"
calamity,
cataclysm,
tragedy,
catastrophe,
disaster an event resulting in great loss and misfortune; "the whole city was affected by the irremediable calamity"; "the earthquake was a disaster"
adversity a stroke of ill fortune; a calamitous event; "a period marked by adversities"
hardship something that causes or entails suffering; "I cannot think it a hardship that more indulgence is allowed to men than to women"- James Boswell; "the many hardships of frontier life"
misfortune -
an unfortunate state resulting from unfavorable outcomes
weakness the property of lacking physical or mental strength; liability to failure under pressure or stress or strain; "his weakness increased as he became older"; "the weakness of the span was overlooked until it collapsed"
